Obetajoč novi inzulin

Za sprostitev

Preiskovani inzulina, poimenovan U300 je osnovan na molekuli glargina, ki jo sicer uporabljajo pri znanem lantusu. Vendar U300 deluje daljši čas in znižuje krvni sladkor bolj enakomerno, delovni izraz za tovrstno učinkovanje v raziskovalnem žargonu je, da ima inzulin bolj »raven« profil.  a "flatter profile". Inzulin povzroča manj hipoglikemičnih epizod.

Rezultati so ohrabrujoči in obetajo, da utegne biti U300 dobra izbira za zdravljenje sladkornih bolnikov  tipa 1 in tipa 2. Najbolj zanimiva je novica v zvezi s hipoglikemijo. V skupini diabetikov tipa 2, ki že uporabljajo dolgodelujoči inzulin, so v študiji zabeležili 23 odstotkov manj bolnikov z nočnimi padci krvnega sladkorja v primerjavi s kontrolno skupino, ki je uporabljala lantus. Gre za opazno razliko.
V povprečju so bili sodelujoči stari 58 let in so imeli 13 let diagnosticiran diabetes. Raziskovalno obdobje je trajalo šest mesecev. Raziskovalci so zabeležili, da je bilo tudi preko dneva manj dogodkov, povezanih z nizkim krvnim sladkorjem.
Zmanjševanje tveganja hipoglikemije je cilj učinkovitega vodenja diabetesa. U300 zmanjšuje to tveganje celo pri bolnikih, ki jemljejo visoke bazalne odmerke inzulina in tablete, vendar jim ne uspe doseči ciljnih vrednosti krvnega sladkorja.
Sanofi ima močan razlog za razvoj nove vrste inzulina, ker bo naslednje leto izgubil patentno zaščito. Idealno v takem primeru je, da ima proizvajalec podobno in še malo boljše novo zdravilo s čimer zaščiti znaten del franšize pred tveganjem podobnih (biosimilarnih) zdravil na tržišču. Ocenjujejo, da bo do leta 2018 prodajat U300 dosegla milijardo dolarjev.
Kaj lahko te številke pomenijo bolnikom? Način, ki se ga farmacevtske družbe poslužujejo za povečevanje profita je tudi ta, da spodbujajo izboljšave pri že obstoječih zdravilih. Razvoj resnično novega zdravila zna namreč biti izjemno drag in dolgo časa trajajoč proces.

JK

 

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